Pld2^tm1Yaka
Targeted Allele Detail

Summary

• Symbol: Pld2^tm1Yaka
• Name: phospholipase D2; targeted mutation 1, Yasunori Kanaho
• MGI ID: MGI:5468333
• Gene: Pld2 Location: Chr11:70430890-70448936 bp, + strand Genetic Position: Chr11, 42.99 cM
• Alliance: Pld2^tm1Yaka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192844
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 14 and 15 were replaced with a floxed neo cassette. Western blot analysis confirmed the absence of protein expression. (J:192844)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pld2 Mutation: 49 strains or lines available

References

• Original: J:192844 Sato T, et al., Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: phospholipase D is dispensable. Mol Cell Biol. 2013 Jan;33(1):136-45
• All: 2 reference(s)