Ccnd3^tm2.1Pisc
Targeted Allele Detail

Summary

• Symbol: Ccnd3^tm2.1Pisc
• Name: cyclin D3; targeted mutation 2.1, Piotr Sicinski
• MGI ID: MGI:5468337
• Synonyms: Ccnd3^F, D3^F
• Gene: Ccnd3 Location: Chr17:47815976-47910614 bp, + strand Genetic Position: Chr17, 23.37 cM
• Alliance: Ccnd3^tm2.1Pisc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192032
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exons 2 through 4 floxed. (J:192032)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccnd3 Mutation: 507 strains or lines available

References

• Original: J:192032 Choi YJ, et al., The requirement for cyclin D function in tumor maintenance. Cancer Cell. 2012 Oct 16;22(4):438-51
• All: 3 reference(s)