Pld1^tm1.1Mafr
Targeted Allele Detail

Summary

• Symbol: Pld1^tm1.1Mafr
• Name: phospholipase D1; targeted mutation 1.1, Michael Frohman
• MGI ID: MGI:5468471
• Gene: Pld1 Location: Chr3:27992844-28187511 bp, + strand Genetic Position: Chr3, 11.15 cM
• Alliance: Pld1^tm1.1Mafr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193451
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 13. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 13. Cre-mediated recombination removed exon 13 and the neo cassette. RT-PCR confirmed the absence of transcript expression in endothelial cells. (J:193451)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pld1 Mutation: 64 strains or lines available

References

• Original: J:193451 Chen Q, et al., Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis. Sci Signal. 2012;5(249):ra79
• All: 9 reference(s)