Ccnd3^{tm1.1(Ccnd2)Iaai}
Targeted Allele Detail

Summary

• Symbol: Ccnd3^{tm1.1(Ccnd2)Iaai}
• Name: cyclin D3; targeted mutation 1.1, Iannis Aifantis
• MGI ID: MGI:5468556
• Synonyms: Ccnd3^Ccnd2, Ccnd3^D2
• Gene: Ccnd3 Location: Chr17:47815976-47910614 bp, + strand Genetic Position: Chr17, 23.37 cM
• Alliance: Ccnd3^{tm1.1(Ccnd2)Iaai} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192031
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequence including introns was replaced with the murine cDNA. Cre-mediated recombination removed the floxed neo cassette downstream of the mouse cDNA. The 5' and 3' untranslated regions remain intact. (J:192031)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccnd3 Mutation: 507 strains or lines available

References

• Original: J:192031 Sawai CM, et al., Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia. Cancer Cell. 2012 Oct 16;22(4):452-65
• All: 1 reference(s)