Tg(Ckm-Chrne*L269F)5Cgz
Transgene Detail
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Symbol: |
Tg(Ckm-Chrne*L269F)5Cgz |
Name: |
transgene insertion 5, Christopher Gomez |
MGI ID: |
MGI:5468686 |
Synonyms: |
epsilonL269F |
Transgene: |
Tg(Ckm-Chrne*L269F)5Cgz Location: unknown
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Alliance: |
Tg(Ckm-Chrne*L269F)5Cgz page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Ckm-Chrne*L269F)5Cgz expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Chrne (MGI:87894) |
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Mutation details: A transgene was generated encoding the murine mutant cholinergic receptor, nicotinic, epsilon polypeptide (Chrne*L269F) under control of a murine creatine kinase, muscle (Ckm) promoter. A point mutation was introduced resulting in the epsilonL269F mutation as present in the affected members of two families with the slow-channel congenital myasthenic syndrome (SCCMS). The 3' untranslated end of the epsilonL269F cDNA was removed and replaced with the 3' UTR pf the neomycin resistance gene (neo) and an intron from the SV40 small t intron. Line 5 was generated.
(J:193524)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:193524 Gomez CM, et al., Slow-channel transgenic mice: a model of postsynaptic organellar degeneration at the neuromuscular junction. J Neurosci. 1997 Jun 1;17(11):4170-9 |
All: |
8 reference(s) |
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