Fcgr2b^tm1Kgcs
Targeted Allele Detail

Summary

• Symbol: Fcgr2b^tm1Kgcs
• Name: Fc receptor, IgG, low affinity IIb; targeted mutation 1, Kenneth G C Smith
• MGI ID: MGI:5468717
• Synonyms: FcgammaRIIb^H1
• Gene: Fcgr2b Location: Chr1:170786186-170804116 bp, - strand Genetic Position: Chr1, 78.02 cM
• Alliance: Fcgr2b^tm1Kgcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180890
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The promoter and the first three exons from haplotype I replaced the endogenous sequence (haplotype III in C57BL/6 ES cells). (J:180890)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcgr2b Mutation: 49 strains or lines available

References

• Original: J:190890 Espeli M, et al., Analysis of a wild mouse promoter variant reveals a novel role for FcgammaRIIb in the control of the germinal center and autoimmunity. J Exp Med. 2012 Nov 19;209(12):2307-19
• All: 3 reference(s)