Vangl2^M1Yzcm
Chemically induced Allele Detail

Summary

• Symbol: Vangl2^M1Yzcm
• Name: VANGL planar cell polarity 2; mutation 1, Yangzhou University Comparative Medicine Center
• MGI ID: MGI:5468724
• Gene: Vangl2 Location: Chr1:171828527-171856011 bp, - strand Genetic Position: Chr1, 79.54 cM
• Alliance: Vangl2^M1Yzcm page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU induced a C/T transition mutation that resulted in substitution of a glutamine codon (Q) for a stop (nonsense) codon at position 449. (J:193593)
• Inheritance: Dominant

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vangl2 Mutation: 34 strains or lines available

References

• Original: J:193593 Chen B, et al., Loop-tail phenotype in heterozygous mice and neural tube defects in homozygous mice result from a nonsense mutation in the Vangl2 gene. Genet Mol Res. 2013 Jan 22;12(AOP)
• All: 1 reference(s)