Sh3gl1^tm1Pdc
Targeted Allele Detail

Summary

• Symbol: Sh3gl1^tm1Pdc
• Name: SH3-domain GRB2-like 1; targeted mutation 1, Pietro De Camilli
• MGI ID: MGI:5468725
• Synonyms: Endo-A2 null
• Gene: Sh3gl1 Location: Chr17:56323750-56343635 bp, - strand Genetic Position: Chr17, 29.11 cM
• Alliance: Sh3gl1^tm1Pdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178947
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All coding exons following exon 1 (exons 2-10) were replaced with a neomycin resistance cassette. Western blot analysis confirmed the absence of protein expression in the brain. (J:178947)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sh3gl1 Mutation: 37 strains or lines available

References

• Original: J:178947 Milosevic I, et al., Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission. Neuron. 2011 Nov 17;72(4):587-601
• All: 8 reference(s)