Sh3gl3^tm1.2Itl
Targeted Allele Detail

Summary

• Symbol: Sh3gl3^tm1.2Itl
• Name: SH3-domain GRB2-like 3; targeted mutation 1.2, inGenious Targeting Laboratory
• MGI ID: MGI:5468729
• Gene: Sh3gl3 Location: Chr7:81824581-81956618 bp, + strand Genetic Position: Chr7, 47.15 cM, cytoband D2-3
• Alliance: Sh3gl3^tm1.2Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178947
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J x 129S1/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed the removed exon 1 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the brain. (J:178947)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh3gl3 Mutation: 17 strains or lines available

References

• Original: J:178947 Milosevic I, et al., Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission. Neuron. 2011 Nov 17;72(4):587-601
• All: 4 reference(s)