Gt(ROSA)26Sor^{tm2(H1/tetO-RNAi:Kdm1a)Arte}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(H1/tetO-RNAi:Kdm1a)Arte}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, TaconicArtemis
• MGI ID: MGI:5468804
• Synonyms: Gt(ROSA)26Sor^{tm1(H1/tetO-RNAi:Kdm1a)Arte}, shLSD1
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(H1/tetO-RNAi:Kdm1a)Arte} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192055
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Knockdown, RMCE-ready)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(H1/tetO-RNAi:Kdm1a)Arte} involves 1 genes/genome features (Kdm1a) View all
• Mutation details: A short hairpin RNA (shRNA) against lysine (K)-specific demethylase 1A gene was placed under the control of the H1-tetO promoter and targeted to Gt(ROSA)26Sor locus by RMCE. (J:192055)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:192055 Sprussel A, et al., Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation. Leukemia. 2012 Sep;26(9):2039-51
• All: 1 reference(s)