Casp4^tm1.1Vmd
Targeted Allele Detail

Summary

• Symbol: Casp4^tm1.1Vmd
• Name: caspase 4, apoptosis-related cysteine peptidase; targeted mutation 1.1, Vishva M Dixit
• MGI ID: MGI:5468949
• Synonyms: Casp4^tm1.1Gne
• Gene: Casp4 Location: Chr9:5308828-5336783 bp, + strand Genetic Position: Chr9, 2.46 cM, cytoband A1
• Alliance: Casp4^tm1.1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193522
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upsteam of exon 5. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 5 and the neo cassette. (J:193522)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp4 Mutation: 33 strains or lines available

References

• Original: J:193522 Kayagaki N, et al., Non-canonical inflammasome activation targets caspase-11. Nature. 2011 Nov 3;479(7371):117-21
• All: 44 reference(s)