Tg(Casp4)#Gne
Transgene Detail

Summary

• Symbol: Tg(Casp4)#Gne
• Name: transgene insertion, Genentech
• MGI ID: MGI:5468960
• Synonyms: Casp11^Tg
• Transgene: Tg(Casp4)#Gne Location: unknown
• Alliance: Tg(Casp4)#Gne page

Transgene origin

• Strain of Origin: 129S2/SvPas

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Casp4)#Gne expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Casp4 (MGI:107700)

• Mutation details: The transgene is composed of a C57BL/6 mouse BAC (RP23-78A8). Exons 1 and 2 of Casp1 were inactivated by replacing them with a FRT-PGK-em7-Neo=FRT cassette. Flp-mediated recombination removed the neo cassette. The transgene was injected into Casp1^tm1Sesh embryos. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:193522)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:193522 Kayagaki N, et al., Non-canonical inflammasome activation targets caspase-11. Nature. 2011 Nov 3;479(7371):117-21
• All: 11 reference(s)