Il7r^tm1.1Asin
Targeted Allele Detail

Summary

• Symbol: Il7r^tm1.1Asin
• Name: interleukin 7 receptor; targeted mutation 1.1, Alfred Singer
• MGI ID: MGI:5468999
• Synonyms: IL-7R^fl
• Gene: Il7r Location: Chr15:9505874-9530262 bp, - strand Genetic Position: Chr15, 4.16 cM
• Alliance: Il7r^tm1.1Asin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190889
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 3. An FRT- and loxP-flanked neo cassette was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exon 3 floxed. (J:190889)

Generation of the Il7r^tm1.1Asin allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il7r Mutation: 31 strains or lines available

References

• Original: J:190889 McCaughtry TM, et al., Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus. J Exp Med. 2012 Nov 19;209(12):2263-76
• All: 10 reference(s)