Il2rg^tm1.1Asin
Targeted Allele Detail

Summary

• Symbol: Il2rg^tm1.1Asin
• Name: interleukin 2 receptor, gamma chain; targeted mutation 1.1, Alfred Singer
• MGI ID: MGI:5469000
• Synonyms: gammac^fl
• Gene: Il2rg Location: ChrX:100307991-100311861 bp, - strand Genetic Position: ChrX, 43.9 cM
• Alliance: Il2rg^tm1.1Asin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190889
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2. An FRT- and loxP-flanked neo cassette was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette and left exons 2 through 6 floxed. (J:190889)

Generation of the Il2rg^tm1.1Asin allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il2rg Mutation: 179 strains or lines available

References

• Original: J:190889 McCaughtry TM, et al., Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus. J Exp Med. 2012 Nov 19;209(12):2263-76
• All: 4 reference(s)