Tlr4^tm1Djh
Targeted Allele Detail

Summary

• Symbol: Tlr4^tm1Djh
• Name: toll-like receptor 4; targeted mutation 1, David J Hackam
• MGI ID: MGI:5469002
• Synonyms: Tlr4^loxP
• Gene: Tlr4 Location: Chr4:66745788-66765338 bp, + strand Genetic Position: Chr4, 34.66 cM
• Alliance: Tlr4^tm1Djh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192520
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The Flp recombinase (flp deleter), which effectively recombined the Frt sites flanking the neo gene, left behind the loxP sites flanking the exon 2. (J:192520, J:193668)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr4 Mutation: 91 strains or lines available

References

• Original: J:192520 Sodhi CP, et al., Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis. Gastroenterology. 2010 Jan;138(1):185-96
• All: 27 reference(s)