Map3k2^tm1Rdbr
Targeted Allele Detail

Summary

• Symbol: Map3k2^tm1Rdbr
• Name: mitogen-activated protein kinase kinase kinase 2; targeted mutation 1, R Dale Brown
• MGI ID: MGI:5469064
• Synonyms: MEKK2^-
• Gene: Map3k2 Location: Chr18:32296142-32369804 bp, + strand Genetic Position: Chr18, 17.95 cM, cytoband B3
• Alliance: Map3k2^tm1Rdbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192835
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced part of the first coding exon through part of the next exon. Western blot analysis confirmed the absence of protein expression in ES cells. (J:193674)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k2 Mutation: 42 strains or lines available

References

• Original: J:192835 Brown RD, et al., MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2013 Jan 15;304(2):H269-81
• All: 2 reference(s)