Tc(HSA7;HSA14)#Mtos
Transgenic Allele Detail

Summary

• Symbol: Tc(HSA7;HSA14)#Mtos
• Name: transchromosomal, human 7 and human 14, Mitsuo Oshimura
• MGI ID: MGI:5469115
• Synonyms: CYP3A-HAC
• Gene: Tc(HSA7;HSA14)#Mtos Location: unknown

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:191214
• Parent Cell Line: TT2F (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tc(HSA7;HSA14)#Mtos expresses 4 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CYP3A4 (1576)

  Cyp3a13

  (MGI:88610)

  human

  CYP3A5 (1577)

  Cyp3a11	(MGI:88609)
  Cyp3a13	(MGI:88610)
  Cyp3a16	(MGI:106099)
  Cyp3a41a	(MGI:1858451)
  Cyp3a41b	(MGI:3714859)
  Cyp3a44	(MGI:2449818)

  human

  CYP3A7 (1551)

  Cyp3a13	(MGI:88610)
  Cyp3a25	(MGI:1930638)
  Cyp3a59	(MGI:3769707)

  human

  CYP3A43 (64816)

  Cyp3a25	(MGI:1930638)
  Cyp3a57	(MGI:3646373)
  Cyp3a59	(MGI:3769707)

• Mutation details: Cre-mediated recombination and telomere seeding resulted in the transfer a portion of human chromosome 7 (from the AC004922 and AF006752; including the CYP3A cluster) onto the human artificial chromosome (HAC; SC20) generated from human chromosome 14. The HAC contains an GFP, loxP site and hygro cassette at AC004922 locus. A xenobiotic-responsive element results in liver-specific expression of the CYP3A-HAC induced by rifampicin treatment. (J:191214)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tc(HSA7;HSA14)#Mtos Mutation: 0 strains or lines available

References

• Original: J:191214 Kazuki Y, et al., Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans. Hum Mol Genet. 2013 Feb 1;22(3):578-92
• All: 2 reference(s)