Del(5Cyp3a57-Cyp3a59)1Mtos
Targeted Allele Detail

Summary

• Symbol: Del(5Cyp3a57-Cyp3a59)1Mtos
• Name: deletion, Chr 5, Mitsuo Oshimura 1
• MGI ID: MGI:5469199
• Synonyms: Cyp3a57-59KO, Del1Mtos
• Gene: Del(5Cyp3a57-Cyp3a59)1Mtos Location: Chr5:145282089-146050097 bp Genetic Position: Chr5, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191214
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(5Cyp3a57-Cyp3a59)1Mtos involves 17 genes/genome features (Cyp3a57, Gm2314, Cyp3a16 ...) View all
• Mutation details: Cre-mediated recombination between Cyp3a57^tm1Mtos and Cyp3a59^tm1Mtos deleted the intervening sequence (including Cyp3a57, Cyp3a16, Cyp3a41b, Cyp3a41a, Cyp3a44, Cyp3a11, Cyp3a25 and Cyp3a59). A PGK promoter, loxP site and GFP remain. (J:191214)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(5Cyp3a57-Cyp3a59)1Mtos Mutation: 1 strain or line available

References

• Original: J:191214 Kazuki Y, et al., Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans. Hum Mol Genet. 2013 Feb 1;22(3):578-92
• All: 4 reference(s)