Vps52^t-w5
Spontaneous Allele Detail

Summary

• Symbol: Vps52^t-w5
• Name: VPS52 GARP complex subunit; t, wild 5
• MGI ID: MGI:5469352
• Gene: Vps52 Location: Chr17:34174786-34186009 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Vps52^t-w5 page

Mutation origin

• Strain of Origin: wild-derived

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide repeat expansion
• Mutation details: A 2 nucleotide insertion of GG is detected at the start of exon 2 in a stretch of consecutive G nucleotides (9 in the wild-type C57BL/6 sequence) resulting in a frameshift mutation that generates a premature termination codon. Western blot analysis with an antibody directed against amino acids 496-509 does not detect the protein band in homozygous embryonic stem cells. This mutation is found in the t^w5 haplotype. (J:190873)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vps52 Mutation: 42 strains or lines available

References

• Original: J:190873 Sugimoto M, et al., Molecular identification of t(w5): Vps52 promotes pluripotential cell differentiation through cell-cell interactions. Cell Rep. 2012 Nov 29;2(5):1363-74
• All: 1 reference(s)