Ralgapa2^tm1Hhor
Targeted Allele Detail

Summary

• Symbol: Ralgapa2^tm1Hhor
• Name: Ral GTPase activating protein, alpha subunit 2 (catalytic); targeted mutation 1, H Horiuchi
• MGI ID: MGI:5469375
• Gene: Ralgapa2 Location: Chr2:146081799-146354264 bp, - strand Genetic Position: Chr2, 71.33 cM
• Alliance: Ralgapa2^tm1Hhor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193368
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES, nlacZ and neo replaced exon 2 and 3. Western blot analysis confirmed the absence of protein in the urinary bladder. (J:193368)

Tumor Data

List all tumor models in MMHCdb carrying Ralgapa2^tm1Hhor

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ralgapa2 Mutation: 118 strains or lines available

References

• Original: J:193368 Saito R, et al., Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer. Oncogene. 2013 Feb 14;32(7):894-902
• All: 3 reference(s)