Rabl2^mot
Chemically induced Allele Detail

Summary

• Symbol: Rabl2^mot
• Name: RAB, member RAS oncogene family-like 2; mot
• MGI ID: MGI:5469381
• Synonyms: Rabl2^D73G
• Gene: Rabl2 Location: Chr15:89466736-89476126 bp, - strand Genetic Position: Chr15, 44.96 cM
• Alliance: Rabl2^mot page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

Allele Type: Chemically induced (ENU) Mutation: Single point mutation Mutation details: ENU induced an A to G transition in exon 5 that results in the amino acid substitution of aspartic acid with glycine at position 73 (D73G). This mutation affects isoforms 1 and 2 but not 3. (J:193640) Inheritance: Recessive

Schematic showing the point mutation in the Rabl2^mot allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rabl2 Mutation: 13 strains or lines available

References

• Original: J:193640 Lo JC, et al., RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet. 2012;8(10):e1002969
• All: 3 reference(s)