Supv3l1^tm1Whle
Targeted Allele Detail

Summary

• Symbol: Supv3l1^tm1Whle
• Name: suppressor of var1, 3-like 1 (S. cerevisiae); targeted mutation 1, Wen-Hwa Lee
• MGI ID: MGI:5469429
• Synonyms: mSuv3^-
• Gene: Supv3l1 Location: Chr10:62264988-62285517 bp, - strand Genetic Position: Chr10, 32.4 cM
• Alliance: Supv3l1^tm1Whle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193361
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into the location corresponding to the human codon 684. This renders the mRNA unstable. (J:193361)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Supv3l1^tm1Whle

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Supv3l1 Mutation: 42 strains or lines available

References

• Original: J:193361 Chen PL, et al., Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan. Oncogene. 2013 Feb 28;32(9):1193-201
• All: 1 reference(s)