Or8a1b^{tm1.1(COP4*/EYFP)Tboz}
Targeted Allele Detail

Summary

• Symbol: Or8a1b^{tm1.1(COP4*/EYFP)Tboz}
• Name: olfactory receptor family 8 subfamily A member 1B; targeted mutation 1.1, Thomas Bozza
• MGI ID: MGI:5469474
• Synonyms: M72-ChR2, M72-ChR2-YFP, M72-IRES-ChR2-YFP
• Gene: Or8a1b Location: Chr9:37622644-37623576 bp, - strand Genetic Position: Chr9, 20.8 cM
• Alliance: Or8a1b^{tm1.1(COP4*/EYFP)Tboz} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240731
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert an internal ribosome entry site (IRES), the ChR2(H134R)-EYFP fusion gene, and a self-excising neo cassette, ACNF, downstream of the olfactory receptor 160 gene. The neo cassette is excised. Only olfactory sensory neurons (OSN) expressing this specific odorant receptor, M72, express ChR2(H134R)-EYFP, rendering them light sensitive. (J:240731)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Or8a1b Mutation: 35 strains or lines available

References

• Original: J:240731 Smear M, et al., Multiple perceptible signals from a single olfactory glomerulus. Nat Neurosci. 2013 Nov;16(11):1687-91
• All: 10 reference(s)