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Or8a1btm1.1(COP4*/EYFP)Tboz
Targeted Allele Detail
Summary
Symbol: Or8a1btm1.1(COP4*/EYFP)Tboz
Name: olfactory receptor family 8 subfamily A member 1B; targeted mutation 1.1, Thomas Bozza
MGI ID: MGI:5469474
Synonyms: M72-ChR2, M72-ChR2-YFP, M72-IRES-ChR2-YFP
Gene: Or8a1b  Location: Chr9:37622644-37623576 bp, - strand  Genetic Position: Chr9, 20.8 cM
Alliance: Or8a1btm1.1(COP4*/EYFP)Tboz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:240731
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert an internal ribosome entry site (IRES), the ChR2(H134R)-EYFP fusion gene, and a self-excising neo cassette, ACNF, downstream of the olfactory receptor 160 gene. The neo cassette is excised. Only olfactory sensory neurons (OSN) expressing this specific odorant receptor, M72, express ChR2(H134R)-EYFP, rendering them light sensitive. (J:240731)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Or8a1b Mutation:  35 strains or lines available
References
Original:  J:240731 Smear M, et al., Multiple perceptible signals from a single olfactory glomerulus. Nat Neurosci. 2013 Nov;16(11):1687-91
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory