Syngap1^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Syngap1^tm1.1Geno
• Name: synaptic Ras GTPase activating protein 1 homolog (rat); targeted mutation 1.1, Genoway
• MGI ID: MGI:5469865
• Synonyms: SYNGAP1^fl
• Gene: Syngap1 Location: Chr17:27160227-27191408 bp, + strand Genetic Position: Chr17, 13.6 cM
• Alliance: Syngap1^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193208
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted usptream of exon 6. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neo cassette and left exons 6 and 7 floxed. (J:193208)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Syngap1 Mutation: 49 strains or lines available

References

• Original: J:193208 Clement JP, et al., Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses. Cell. 2012 Nov 9;151(4):709-23
• All: 7 reference(s)