Syngap1^tm2Geno
Targeted Allele Detail

Summary

• Symbol: Syngap1^tm2Geno
• Name: synaptic Ras GTPase activating protein 1 homolog (rat); targeted mutation 2, Genoway
• MGI ID: MGI:5469866
• Synonyms: SYNGAP1^lx-st
• Gene: Syngap1 Location: Chr17:27160227-27191408 bp, + strand Genetic Position: Chr17, 13.6 cM
• Alliance: Syngap1^tm2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193208
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted into intron 5. Western blot analysis confirmed reduced protein expression in heterozygous samples. Cre-mediated recombination is required to remove the neo cassette and restore protein expression. (J:193208)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Syngap1 Mutation: 49 strains or lines available

References

• Original: J:193208 Clement JP, et al., Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses. Cell. 2012 Nov 9;151(4):709-23
• All: 3 reference(s)