Mirc34^tm1.1Cxu
Targeted Allele Detail

Summary

• Symbol: Mirc34^tm1.1Cxu
• Name: microRNA cluster 34, including Mir449a through Mir449c; targeted mutation 1.1, Chen Xu
• MGI ID: MGI:5469885
• Synonyms: Mir449^-
• Gene: Mirc34 Location: Chr13:113172517-113174158 bp Genetic Position: Chr13, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192995
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT flanked PGK-neomycin selection cassette was inserted in intron 2 of the Cdc20b locus replacing sequences encoding Mir449a, Mir449b, and Mir449c. The selection cassette was subsequently excised by flp recombinase expression. (J:192995)

Expression

In Mice Carrying this Mutation:

44 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc34 Mutation: 1 strain or line available

References

• Original: J:192995 Bao J, et al., MicroRNA-449 and microRNA-34b/c function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway. J Biol Chem. 2012 Jun 22;287(26):21686-98
• All: 5 reference(s)