Scyl1^tm1.1Spel
Targeted Allele Detail

Summary

• Symbol: Scyl1^tm1.1Spel
• Name: SCY1-like 1 (S. cerevisiae); targeted mutation 1.1, Stephane Pelletier
• MGI ID: MGI:5469960
• Gene: Scyl1 Location: Chr19:5808450-5821461 bp, - strand Genetic Position: Chr19, 4.34 cM
• Alliance: Scyl1^tm1.1Spel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192445
• Parent Cell Line: CMTI-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted downstream of exon 1. A FLAG-tag and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 17. Flp-mediated recombination removed the neo cassette and left exons 2 through 17 floxed. Western blot analysis confirmed the absence of protein expression in the cerebrum. (J:192445)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scyl1 Mutation: 21 strains or lines available

References

• Original: J:192445 Pelletier S, et al., An early onset progressive motor neuron disorder in Scyl1-deficient mice is associated with mislocalization of TDP-43. J Neurosci. 2012 Nov 21;32(47):16560-73
• All: 5 reference(s)