Cbfbtm5Ppl
Targeted Allele Detail
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Symbol: |
Cbfbtm5Ppl |
Name: |
core binding factor beta; targeted mutation 5, Pu P Liu |
MGI ID: |
MGI:5469976 |
Synonyms: |
CbfbdeltaC95, Cbfb-MYH11deltaC95 |
Gene: |
Cbfb Location: Chr8:105897306-105944621 bp, + strand Genetic Position: Chr8, 53.04 cM
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Alliance: |
Cbfbtm5Ppl page
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Germline Transmission: |
Earliest citation of germline transmission:
J:193140
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout) |
Mutation: |
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Insertion
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Mutation details: Exon 5 was replaced by a construct composed of the first 25 bp of mouse exon 5 fused to the 3' end of a human CBFB/MYH11 cDNA. This fusion protein is produced by a chromosome 16 inversion in patients with acute myeloid leukemia subtype M4Eo. The human cDNA fragment used contained the last 66 bp of human exon 5 and exons 33-42 of MYH11 lacking the sequence encoding amino acids the last 95 amino acids (deltaC95). A bovine growth hormone polyadenylation site and a floxed PGK-neomycin cassette were inserted immediately downstream.
(J:193140)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cbfb Mutation: |
36 strains or lines available
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Original: |
J:193140 Kamikubo Y, et al., The C-terminus of CBFbeta-SMMHC is required to induce embryonic hematopoietic defects and leukemogenesis. Blood. 2013 Jan 24;121(4):638-42 |
All: |
1 reference(s) |
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