Pfn1tm1Foxp
Targeted Allele Detail
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Symbol: |
Pfn1tm1Foxp |
Name: |
profilin 1; targeted mutation 1, Paul L Fox |
MGI ID: |
MGI:5470084 |
Synonyms: |
Pfn1flox:Y129F |
Gene: |
Pfn1 Location: Chr11:70542676-70545470 bp, - strand Genetic Position: Chr11, 43.21 cM, cytoband A-D
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Alliance: |
Pfn1tm1Foxp page
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Germline Transmission: |
Earliest citation of germline transmission:
J:193938
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutations: |
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Insertion, Single point mutation
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Mutation details: Exon 3 was floxed. A modified exon 3 with an A to T transversion that results in the amino acid substitution of phenylalanine for tyrsorine at position 129 (Y129F). Cre-mediated recombination is required to remove the wild-type exon 3 and allow for expression of the modified exon 3.
(J:193938)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: C57BL/6NTac | | | | involves: C57BL/6 * C57BL/6NTac * SJL | | | | involves: C57BL/6NTac | |
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Phenotypes: |
Affected Systems |
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cardiovascular system
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√
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decreased angiogenesis
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√
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√
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abnormal vascular endothelial cell migration
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√
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abnormal vascular wound healing
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√
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cellular
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√
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abnormal vascular endothelial cell migration
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√
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homeostasis/metabolism
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√
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abnormal vascular wound healing
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√
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delayed wound healing
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√
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normal phenotype
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√
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no abnormal phenotype detected
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pfn1 Mutation: |
12 strains or lines available
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Original: |
J:193938 Fan Y, et al., Stimulus-dependent phosphorylation of profilin-1 in angiogenesis. Nat Cell Biol. 2012 Oct;14(10):1046-56 |
All: |
1 reference(s) |
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