Pfn1^tm1Foxp
Targeted Allele Detail

Summary

• Symbol: Pfn1^tm1Foxp
• Name: profilin 1; targeted mutation 1, Paul L Fox
• MGI ID: MGI:5470084
• Synonyms: Pfn1^flox:Y129F
• Gene: Pfn1 Location: Chr11:70542676-70545470 bp, - strand Genetic Position: Chr11, 43.21 cM, cytoband A-D
• Alliance: Pfn1^tm1Foxp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193938
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 3 was floxed. A modified exon 3 with an A to T transversion that results in the amino acid substitution of phenylalanine for tyrsorine at position 129 (Y129F). Cre-mediated recombination is required to remove the wild-type exon 3 and allow for expression of the modified exon 3. (J:193938)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pfn1 Mutation: 12 strains or lines available

References

• Original: J:193938 Fan Y, et al., Stimulus-dependent phosphorylation of profilin-1 in angiogenesis. Nat Cell Biol. 2012 Oct;14(10):1046-56
• All: 1 reference(s)