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Pfn1tm1Foxp
Targeted Allele Detail
Summary
Symbol: Pfn1tm1Foxp
Name: profilin 1; targeted mutation 1, Paul L Fox
MGI ID: MGI:5470084
Synonyms: Pfn1flox:Y129F
Gene: Pfn1  Location: Chr11:70542676-70545470 bp, - strand  Genetic Position: Chr11, 43.21 cM, cytoband A-D
Alliance: Pfn1tm1Foxp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193938
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Single point mutation
 
Mutation detailsExon 3 was floxed. A modified exon 3 with an A to T transversion that results in the amino acid substitution of phenylalanine for tyrsorine at position 129 (Y129F). Cre-mediated recombination is required to remove the wild-type exon 3 and allow for expression of the modified exon 3. (J:193938)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: C57BL/6NTac
 
involves: C57BL/6 * C57BL/6NTac * SJL
 
involves: C57BL/6NTac
 
Phenotypes:
Affected Systems
show or hide all annotated terms
     
cardiovascular system
decreased angiogenesis
abnormal vascular endothelial cell migration
abnormal vascular wound healing
cellular
abnormal vascular endothelial cell migration
homeostasis/metabolism
abnormal vascular wound healing
delayed wound healing
normal phenotype
no abnormal phenotype detected
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pfn1 Mutation:  12 strains or lines available
References
Original:  J:193938 Fan Y, et al., Stimulus-dependent phosphorylation of profilin-1 in angiogenesis. Nat Cell Biol. 2012 Oct;14(10):1046-56
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory