Psmc4^tm1.1Ryot
Targeted Allele Detail

Summary

• Symbol: Psmc4^tm1.1Ryot
• Name: proteasome (prosome, macropain) 26S subunit, ATPase, 4; targeted mutation 1.1, Ryosuke Takahashi
• MGI ID: MGI:5470093
• Synonyms: Rpt3flox
• Gene: Psmc4 Location: Chr7:27741127-27749517 bp, - strand Genetic Position: Chr7, 16.11 cM
• Alliance: Psmc4^tm1.1Ryot page

Limb clasping and severe kyphosis in Psmc4^tm1.1Ryot/Psmc4^tm1.2Ryot Tg(SLC18A3-cre)KMisa/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193770
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 7. An additional loxP site was inserted downstream of exon 10. Flp-mediated recombination removed the neo cassette and left exons 7 through 10 floxed. (J:193770)

Generation of the Psmc4^tm1.1Ryot and Psmc4^tm1.2Ryot alleles

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psmc4 Mutation: 18 strains or lines available

References

• Original: J:193770 Tashiro Y, et al., Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis. J Biol Chem. 2012 Dec 14;287(51):42984-94
• All: 5 reference(s)