Nol3^tm1.1Rnkt
Targeted Allele Detail

Summary

• Symbol: Nol3^tm1.1Rnkt
• Name: nucleolar protein 3 (apoptosis repressor with CARD domain); targeted mutation 1.1, Richard N Kitsis
• MGI ID: MGI:5470099
• Synonyms: Nol3^-
• Gene: Nol3 Location: Chr8:106002777-106008571 bp, + strand Genetic Position: Chr8, 53.04 cM, cytoband D1
• Alliance: Nol3^tm1.1Rnkt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193803
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 4. Cre-mediated recombination removed exons 2 through 4 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the lungs. (J:193803)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nol3 Mutation: 9 strains or lines available

References

• Original: J:193803 Zaiman AL, et al., A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension. Circulation. 2011 Dec 6;124(23):2533-42
• All: 8 reference(s)