Zic3^tm2.1Jwb
Targeted Allele Detail

Summary

• Symbol: Zic3^tm2.1Jwb
• Name: zinc finger protein of the cerebellum 3; targeted mutation 2.1, John W Belmont
• MGI ID: MGI:5470150
• Synonyms: Zic3^flox
• Gene: Zic3 Location: ChrX:57075988-57081990 bp, + strand Genetic Position: ChrX, 32.56 cM
• Alliance: Zic3^tm2.1Jwb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192577
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed. (J:192577)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zic3 Mutation: 38 strains or lines available

References

• Original: J:192577 Jiang Z, et al., Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left-right patterning and heart development. Hum Mol Genet. 2013 Mar 1;22(5):879-89
• All: 1 reference(s)