Rr96^tm1.1Tich
Targeted Allele Detail

Summary

• Symbol: Rr96^tm1.1Tich
• Name: regulatory region 96; targeted mutation 1.1, Tian Chi
• MGI ID: MGI:5470225
• Synonyms: Cd^*, Cd4^tm1.1Tich
• Gene: Rr96 Location: Chr6:124862841-124863329 bp Genetic Position: Chr6, Syntenic
• Alliance: Rr96^tm1.1Tich page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191711
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Insertion
• Mutation details: A tetO sequence followed by a loxP site and then an FRT flanked neomycin selection cassette were inserted immediately upstream of the Cd4 silencer sequence in intron 1. A second loxP site was inserted immediately downstream of the silencer. The selection cassette was subsequently removed by flp recombinase expression. (J:191711)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr96 Mutation: 0 strains or lines available

References

• Original: J:191711 Wan M, et al., A general approach for controlling transcription and probing epigenetic mechanisms: application to the CD4 locus. J Immunol. 2013 Jan 15;190(2):737-47
• All: 1 reference(s)