Polg2^tm1Wcc
Targeted Allele Detail

Summary

• Symbol: Polg2^tm1Wcc
• Name: polymerase (DNA directed), gamma 2, accessory subunit; targeted mutation 1, William C Copeland
• MGI ID: MGI:5470226
• Synonyms: Polg2^loxp
• Gene: Polg2 Location: Chr11:106659079-106670363 bp, - strand Genetic Position: Chr11, 70.01 cM, cytoband E1
• Alliance: Polg2^tm1Wcc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192568
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5. A floxed neo cassette was inserted downstream of exon 7. (J:192568)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Polg2 Mutation: 25 strains or lines available

References

• Original: J:192568 Humble MM, et al., Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance. Hum Mol Genet. 2013 Mar 1;22(5):1017-25
• All: 1 reference(s)