Pkd1^tm1Fqi
Targeted Allele Detail

Summary

• Symbol: Pkd1^tm1Fqi
• Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Feng Qian
• MGI ID: MGI:5470240
• Synonyms: Pkd1^NeoV
• Gene: Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
• Alliance: Pkd1^tm1Fqi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127628
• Parent Cell Line: CMTI-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted Mutation: Nucleotide substitutions Mutation details: The codon ACT (Thr) was mutated to GTT (Val) at amino acid position 3041 of the cleavage site HL^T^3041. The T3041V mutation is expected to disrupt cleavage of PKD1. In addition a Neo cassette was introduced to aid with selection. (J:127628)

Generation of the Pkd1^tm1Fqi and Pkd1^tm1.1Fqi alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd1 Mutation: 154 strains or lines available

References

• Original: J:127628 Yu S, et al., Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18688-93
• All: 1 reference(s)