Hoxb2^tm2.2Fmr
Targeted Allele Detail

Summary

• Symbol: Hoxb2^tm2.2Fmr
• Name: homeobox B2; targeted mutation 2.2, Filippo M Rijli
• MGI ID: MGI:5470287
• Synonyms: Hoxb2^del
• Gene: Hoxb2 Location: Chr11:96242458-96244846 bp, + strand Genetic Position: Chr11, 59.85 cM
• Alliance: Hoxb2^tm2.2Fmr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193058
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neo cassette with a 3' loxP site was inserted into the intron downstream of the translation start codon. An additional loxP site was inserted downstream of the translation stop codon. Flp-mediated recombination removed the neo cassette and left most of the coding sequence floxed. Cre-mediated recombination removed most of the coding sequence. (J:193058)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxb2 Mutation: 12 strains or lines available

References

• Original: J:193058 Miguez A, et al., Opposing roles for Hoxa2 and Hoxb2 in hindbrain oligodendrocyte patterning. J Neurosci. 2012 Nov 28;32(48):17172-85
• All: 1 reference(s)