B4gat1^m1Ddg
Chemically induced Allele Detail

Summary

• Symbol: B4gat1^m1Ddg
• Name: beta-1,4-glucuronyltransferase 1; mutation 1, David D Ginty
• MGI ID: MGI:5470461
• Synonyms: B3gnt1^M155T, Line 1157
• Gene: B4gat1 Location: Chr19:5088854-5091159 bp, + strand Genetic Position: Chr19, 4.23 cM
• Alliance: B4gat1^m1Ddg page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU induced a T to C transversion in exon 1 in Line 1157 that results in a methionine to threonine (M155T) amino acid substitution in the catalytic domain. This allele is hypomorphic. (J:194150)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any B4gat1 Mutation: 18 strains or lines available

References

• Original: J:194150 Wright KM, et al., Dystroglycan organizes axon guidance cue localization and axonal pathfinding. Neuron. 2012 Dec 6;76(5):931-44
• All: 2 reference(s)