Nfatc1^tm1.1(cre)Bz
Targeted Allele Detail

Summary

• Symbol: Nfatc1^tm1.1(cre)Bz
• Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1.1, Bin Zhou
• MGI ID: MGI:5471107
• Synonyms: Nfatc1^Cre
• Gene: Nfatc1 Location: Chr18:80649420-80756286 bp, - strand Genetic Position: Chr18, 53.66 cM, cytoband E4
• Alliance: Nfatc1^tm1.1(cre)Bz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193198
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Nfatc1^tm1.1(cre)Bz expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nfatc1 (MGI:102469)

• Mutation details: A cassette containing an IRES-cre cDNA sequence and frt-flanked PGK-hygromycin selection marker was inserted into the 3' UTR (after the stop codon) of the Nfatc1 gene in R1 ES cells. Correctly targeted cells were selected and expanded, followed by blastocyst injection. Two lines were selected and crossed to E2A-flpe expressing mice to remove the selection marker. (J:193198)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nfatc1 (mouse) Summary of all recombinase alleles driven by Nfatc1. Comparative matrix view of recombinase activities Alliance mouse Nfatc1 gene page

Disease models

Expression

In Mice Carrying this Mutation:

117 assay results 5 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfatc1 Mutation: 49 strains or lines available

References

• Original: J:193198 Wu B, et al., Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling. Cell. 2012 Nov 21;151(5):1083-96
• All: 50 reference(s)