Gnai2^tm2.1Lbi
Targeted Allele Detail

Summary

• Symbol: Gnai2^tm2.1Lbi
• Name: G protein subunit alpha i2; targeted mutation 2.1, Lutz Birnbaumer
• MGI ID: MGI:5471645
• Synonyms: Galphai2^flx, Gnai2^flx
• Gene: Gnai2 Location: Chr9:107491324-107512542 bp, - strand Genetic Position: Chr9, 58.43 cM
• Alliance: Gnai2^tm2.1Lbi page

Rib fusion phenotype is enhanced in Gnai3^tm1Lbi/Gnai3^tm1Lbi mice by loss of Gnai2 in cartilage

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194587
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2 and a floxed pgk-neo cassette was inserted downstream of exon 4 via homologous recombination. Cre mediated recombination removed the neo cassette. (J:194587)

Generation of the Gnai2^tm2.1Lbi allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnai2 Mutation: 56 strains or lines available

References

• Original: J:194587 Ustyugova IV, et al., IEX-1 deficiency protects against colonic cancer. Mol Cancer Res. 2012 Jun;10(6):760-7
• All: 15 reference(s)