Dlk1^tm1.2Jvs
Targeted Allele Detail

Summary

• Symbol: Dlk1^tm1.2Jvs
• Name: delta like non-canonical Notch ligand 1; targeted mutation 1.2, Jennifer V Schmidt
• MGI ID: MGI:5471922
• Synonyms: Dlk1^cons
• Gene: Dlk1 Location: Chr12:109418749-109429262 bp, + strand Genetic Position: Chr12, 60.17 cM, cytoband E-F1
• Alliance: Dlk1^tm1.2Jvs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194130
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed a neo selection cassette and the last two exons (5 and 6). Northern blot analysis confirmed severely reduced level of transcript expression in E12.5 embryo and placenta when this allele is inherited paternally. (J:194130)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlk1 Mutation: 34 strains or lines available

Notes

Phenotypes observed are dependent on parental source of the allele.

References

• Original: J:194130 Appelbe OK, et al., Conditional deletions refine the embryonic requirement for Dlk1. Mech Dev. 2013 Feb;130(2-3):143-59
• All: 1 reference(s)