Dot1l^tm1.1Wezh
Targeted Allele Detail

Summary

• Symbol: Dot1l^tm1.1Wezh
• Name: DOT1 like histone lysine methyltransferase; targeted mutation 1.1, Wenzheng Zhang
• MGI ID: MGI:5471952
• Synonyms: Dot1l^f
• Gene: Dot1l Location: Chr10:80591040-80631295 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Dot1l^tm1.1Wezh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194304
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette and left exon 5 floxed. (J:194304)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dot1l Mutation: 72 strains or lines available

References

• Original: J:194304 Chang MJ, et al., Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes. Cancer Res. 2010 Dec 15;70(24):10234-42
• All: 6 reference(s)