Nlrp1a^Neut1
Chemically induced Allele Detail

Summary

• Symbol: Nlrp1a^Neut1
• Name: NLR family, pyrin domain containing 1A; neutrophilia 1
• MGI ID: MGI:5471965
• Synonyms: Nlrp1a^Q593P
• Gene: Nlrp1a Location: Chr11:70983062-71035530 bp, - strand Genetic Position: Chr11, 43.21 cM
• Alliance: Nlrp1a^Neut1 page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutations were induced in C57BL/6 male mice. offspring of treated mice were screened for neutrophilia. A point mutation was found in these mice that caused a Glutamine to Proline change in codon 593. (J:191055)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp1a Mutation: 64 strains or lines available

References

• Original: J:191055 Masters SL, et al., NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells. Immunity. 2012 Dec 14;37(6):1009-23
• All: 3 reference(s)