Gt(ROSA)26Sor^{tm1(RICTOR)Jger}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(RICTOR)Jger}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Joseph Gera
• MGI ID: MGI:5471977
• Synonyms: Rictor^loxP, Rosa26hRictor^loxP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(RICTOR)Jger} page

Gliomas in Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger} Tg(GFAP-cre)25Mes/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192206
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(RICTOR)Jger} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RICTOR (253260)

  Rictor

  (MGI:1926007)

• Mutation details: A transgene containing a floxed neo/STOP cassette and myc-tagged human cDNA into the locus. Cre-mediated recombination is required to remove the neo/STOP cassette and achieve expression of the cDNA. (J:192206)

Generation of the Gt(ROSA)26Sor^{tm1(RICTOR)Jger} allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:192206 Bashir T, et al., Conditional astroglial Rictor overexpression induces malignant glioma in mice. PLoS One. 2012;7(10):e47741
• All: 1 reference(s)