Tg(GFAP-EGFR*,-lacZ)#Agu
Transgene Detail

Summary

• Symbol: Tg(GFAP-EGFR*,-lacZ)#Agu
• Name: transgene insertion, Abhijit Guha
• MGI ID: MGI:5472013
• Synonyms: GFAP-EGFRvIII
• Transgene: Tg(GFAP-EGFR*,-lacZ)#Agu Location: unknown
• Alliance: Tg(GFAP-EGFR*,-lacZ)#Agu page

Increased grade of oligodendroglioma in Gt(ROSA)26Sor^{tm1(RICTOR)Jger}/Gt(ROSA)26Sor^{tm1(RICTOR)Jger} Tg(GFAP-EGFR*,-lacZ)#Agu/0 Tg(GFAP-cre)25Mes/0 mice

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The human promoter drives astrocyte-specific expression of the human cDNA with cDNA encoding the constitutively active mutant with an in-frame deletion of exons 2 through 7 in the extracellular domain, an IRES sequence and lacZ gene. The pound symbol is used when no line is specified and/or lines are pooled. (J:85316)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:85316 Ding H, et al., Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model. Cancer Res. 2003 Mar 1;63(5):1106-13
• All: 2 reference(s)