Del(11Nlrp1a-Nlrp1c-ps)1Smas
Targeted Allele Detail

Summary

• Symbol: Del(11Nlrp1a-Nlrp1c-ps)1Smas
• Name: deletion, Chr 11, Seth Masters
• MGI ID: MGI:5472123
• Synonyms: Nlrp1^-, Nlrp1abc^-/-
• Gene: Del(11Nlrp1a-Nlrp1c-ps)1Smas Location: Chr11:70983062-71176058 bp Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191055
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(11Nlrp1a-Nlrp1c-ps)1Smas involves 4 genes/genome features (Nlrp1a, Nlrp1b, Gm23266 ...) View all
• Mutation details: Micer plasmid MHPP282m18 was first inserted in intron 10 of Nlrp1a and Micer plasmid MHPN379g03 was then inserted in cis orientation to the first insertion about 65 kb in the telomeric direction away from Nlrp1c-ps. Transient cre expression then excised all sequence between the two loxP sites in the two insertions. This deleted the base pair region between 71,105,252 and 71,350,339 (Build 38) and removes the first 10 exons of Nlrp1a and all of Nlrp1b and Nlrp1c-ps. (J:191055)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(11Nlrp1a-Nlrp1c-ps)1Smas Mutation: 1 strain or line available

References

• Original: J:191055 Masters SL, et al., NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells. Immunity. 2012 Dec 14;37(6):1009-23
• All: 9 reference(s)