Cd200r1^tm1Eakj
Targeted Allele Detail

Summary

• Symbol: Cd200r1^tm1Eakj
• Name: CD200 receptor 1; targeted mutation 1, Evelyn A Kurt-Jones
• MGI ID: MGI:5472130
• Gene: Cd200r1 Location: Chr16:44586141-44615341 bp, + strand Genetic Position: Chr16, 29.08 cM, cytoband B5
• Alliance: Cd200r1^tm1Eakj page

Decreased susceptibility of Cd200r1^tm1Eakj/Cd200r1^tm1Eakj mice to HSV-1 viral infection

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192198
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion A neo cassette replaced exon 1. Flow cytometry confirmed the absence of protein in macrophages. (J:192198)

Generation of the Cd200r1^tm1Eakj allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd200r1 Mutation: 33 strains or lines available

References

• Original: J:192198 Soberman RJ, et al., CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2. PLoS One. 2012;7(10):e47740
• All: 2 reference(s)