Nmnat2^{Tn(sb-Tyr)2172.P9KK4BOve}
Transposon induced Allele Detail

Summary

• Symbol: Nmnat2^{Tn(sb-Tyr)2172.P9KK4BOve}
• Name: nicotinamide nucleotide adenylyltransferase 2; targeted mutation 2172.P9KK4B, Paul A Overbeek
• MGI ID: MGI:5473270
• Synonyms: Nmnat2^blad, OVB2172-P9KK4B
• Gene: Nmnat2 Location: Chr1:152830744-152995007 bp, + strand Genetic Position: Chr1, 65.15 cM
• Alliance: Nmnat2^{Tn(sb-Tyr)2172.P9KK4BOve} page

Distended bladder, urogenital tract damage, underdeveloped diaphragm, and decreased skeletal muscle mass in Nmnat2^{Tn(sb-Tyr)2172.P9KK4BOve}/Nmnat2^{Tn(sb-Tyr)2172.P9KK4BOve} E18.5 pups

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: Not Specified

Mutation description

Allele Type: Transposon induced Mutation: Insertion Mutation details: The transgenic transposon TgTn(sb-Tyr)2172Ove inserted into intron 1. Western blot analysis confirmed the absence of protein expression in E18.5 brains. (J:192196)

Diagram of the localization of the transposon that generates the Nmnat2^Tn(sb-Tyr)2172.P9KK4BOve allele

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nmnat2 Mutation: 271 strains or lines available

Notes

The original founder also possessed transposon insertion sites in chromosome 8 and 9. However, neither additional insertion was in a gene and the insertion in chromosome 8 was bred out without affecting phenotype.

References

• Original: J:192196 Hicks AN, et al., Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo. PLoS One. 2012;7(10):e47869
• All: 5 reference(s)