Guca1a^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Guca1a^tm1Itl
• Name: guanylate cyclase activator 1a (retina); targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:5473300
• Gene: Guca1a Location: Chr17:47705483-47711509 bp, - strand Genetic Position: Chr17, 23.07 cM, cytoband D
• Alliance: Guca1a^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192199
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette with a translation termination site replaced exon 1. Western blot analysis confirmed the absence of protein expression in the retina. (J:192199)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Guca1a Mutation: 12 strains or lines available

References

• Original: J:192199 Makino CL, et al., Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice. PLoS One. 2012;7(10):e47637
• All: 2 reference(s)