Tg(Rlbp1-cre/ERT2,-EGFP)1Wshn
Transgene Detail

Summary

• Symbol: Tg(Rlbp1-cre/ERT2,-EGFP)1Wshn
• Name: transgene insertion 1, Weiyong Shen
• MGI ID: MGI:5473306
• Synonyms: Rblp1-CreER
• Transgene: Tg(Rlbp1-cre/ERT2,-EGFP)1Wshn Location: unknown
• Alliance: Tg(Rlbp1-cre/ERT2,-EGFP)1Wshn page

Transgene origin

• Strain of Origin: C57BL/6J x CBA

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Rlbp1-cre/ERT2,-EGFP)1Wshn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Rlbp1

• Mutation details: A 2.6 kb fragment of the Rlbp1 gene regulatory region (Rlbp1 promoter, exons 1 and 2 and intron 1) shown to drive Muller cell-specific gene expression was generated by PCR and cloned into a plasmid vector with a cre/ERT2 sequence separeted by IRES and EGFP-pA. The resulting 7 kb construct was linearized and injected into single-cell embryos. Founder information is not available. (J:192243)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Rlbp1 (species not specified) Summary of all recombinase alleles driven by Rlbp1. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:192243 Shen W, et al., Conditional Mullercell ablation causes independent neuronal and vascular pathologies in a novel transgenic model. J Neurosci. 2012 Nov 7;32(45):15715-27
• All: 16 reference(s)