Otx2^{tm1.1(cre/ERT2)Mgoe}
Targeted Allele Detail

Summary

• Symbol: Otx2^{tm1.1(cre/ERT2)Mgoe}
• Name: orthodenticle homeobox 2; targeted mutation 1.1, Magdalena Goetz
• MGI ID: MGI:5473314
• Synonyms: Otx2CreER
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^{tm1.1(cre/ERT2)Mgoe} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194049
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Otx2^{tm1.1(cre/ERT2)Mgoe} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Otx2 (MGI:97451)

• Mutation details: A cassette consisting of the cre/ERT2 sequence followed by the Otx2 3' UTR with the polyadenylation signal (and floxed neo marker) replaced the entire coding sequence of Otx2 following homologous recombination in ES cells. Founder animals were bred to CMV-deleter mice to remove the neo. (J:194049)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Otx2 (mouse) Summary of all recombinase alleles driven by Otx2. Alliance mouse Otx2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:194049 Johansson PA, et al., The transcription factor Otx2 regulates choroid plexus development and function. Development. 2013 Mar;140(5):1055-66
• All: 2 reference(s)